XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy

Abstract excerpt

Endoplasmic reticulum (ER) stress has been extensively described in many protein misfolding disorders including amyotrophic lateral sclerosis (ALS). Adaptation to ER stress is mediated by the activation of an integrated signal transduction pathway known as the unfolded protein response (UPR). We have recently defined the contribution of X Box binding protein-1 (XBP-1) to ALS, a key UPR transcription factor that...

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