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Article

The interplay between tauopathy and aging through interruption of UPR/Nrf2/autophagy crosstalk in the Alzheimer’s disease transgenic experimental models

3 May 2023

Abstract excerpt

PURPOSE: Alzheimer's disease (AD) is the most common form of tauopathy that usually occursduring aging and unfolded protein response (UPR), oxidative stress and autophagy play a crucialrole in tauopathy-induced neurotoxicity. The aim of this study was to investigate the effects oftauopathy on normal brain aging in a Drosophila model of AD. METHOD: We investigated the interplay between aging (10, 20, 30, and 40...

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PMID: 37132251
DOI: 10.1080/00207454.2023.2210409

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