Article
Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans.
Science (New York, N.Y.) - 24 Jan 2020
Frakes Ashley E, Metcalf Melissa G, Tronnes Sarah U, Bar-Ziv Raz, Durieux Jenni, Gildea Holly K, Kandahari Nazineen, Monshietehadi Samira, Dillin Andrew
Abstract excerpt
The ability of the nervous system to sense cellular stress and coordinate protein homeostasis is essential for organismal health. Unfortunately, stress responses that mitigate disturbances in proteostasis, such as the unfolded protein response of the endoplasmic reticulum (UPRER), become defunct with age. In this work, we expressed the constitutively active UPRER transcription factor, XBP-1s, in a subset of...
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