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Article

Opposing Activities Protect Against Age-Onset Proteotoxicity

10 Aug 2006

Abstract excerpt

Aberrant protein aggregation is a common feature of late-onset neurodegenerative diseases, including Alzheimer's disease, which is associated with the misassembly of the Abeta(1-42) peptide. Aggregation-mediated Abeta(1-42) toxicity was reduced in Caenorhabditis elegans when aging was slowed by decreased insulin/insulin growth factor-1-like signaling (IIS). The downstream transcription factors, heat shock factor...

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Identifiers

PMID: 16902091
DOI: 10.1126/science.1124646

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