Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal Cancer.

doi:10.1053/j.gastro.2021.04.042

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Article

Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal Cancer.

Gastroenterology - 1 Aug 2021

Rajamäki Kristiina, Taira Aurora, Katainen Riku, Välimäki Niko, Kuosmanen Anna, Plaketti Roosa-Maria, Seppälä Toni T, Ahtiainen Maarit, Wirta Erkki-Ville, Vartiainen Emilia, Sulo Päivi, Ravantti Janne, Lehtipuro Suvi, Granberg Kirsi J, Nykter Matti, Tanskanen Tomas, Ristimäki Ari, Koskensalo Selja, Renkonen-Sinisalo Laura, Lepistö Anna, Böhm Jan, Taipale Jussi, Mecklin Jukka-Pekka, Aavikko Mervi, Palin Kimmo, Aaltonen Lauri A

Abstract excerpt

BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC (IBD-CRC) may represent a distinct pathway of tumorigenesis compared to sporadic CRC (sCRC). Our aim was to comprehensively characterize IBD-associated tumorigenesis integrating multiple high-throughput approaches, and to compare the...

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PMID: 33930428
DOI: 10.1053/j.gastro.2021.04.042

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