Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development

27 Sept 2019

Abstract excerpt

Abstract Background Toll-like receptor 4 (TLR4) is well known for activating the innate immune system; however, it is also highly expressed in adaptive immune cells, such as CD4+ T-helper 17 (Th17) cells, which play a key role in multiple sclerosis (MS) pathology. However, the function and governing mechanism of TLR4 in Th17 remain unclear. Methods The changes of TLR4 in CD4+ T cells from MS patients and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to MicroRNA in disease regulation
Share to Multiple Sclerosis Research Studies
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31561751
DOI: 10.1186/s12974-019-1579-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis developmentPMID 31561751Read ↗

miR-20b Suppresses Th17 Differentiation and the Pathogenesis of Experimental Autoimmune Encephalomyelitis by Targeting RORγt and STAT3Semantic proximity Read ↗

miR-141 and miR-200a, Revelation of New Possible Players in Modulation of Th17/Treg Differentiation and Pathogenesis of Multiple SclerosisSemantic proximity Read ↗

miRNA-485 Regulates Th17 Generation and Pathogenesis in Experimental Autoimmune Encephalomyelitis through Targeting STAT3Semantic proximity Read ↗

MiR-9-5p and miR-106a-5p dysregulated in CD4+ T-cells of multiple sclerosis patients and targeted essential factors of T helper17/regulatory T-cells differentiation.Semantic proximity Read ↗

Roles of T helper 17 cells and interleukin‐17 in neuroautoimmune diseases with emphasis on multiple sclerosis and Guillain‐Barré syndrome as well as their animal modelsSemantic proximity Read ↗

miRNAs Alter T Helper 17 Cell Fate in the Pathogenesis of Autoimmune DiseasesSemantic proximity Read ↗

Th17 Cell, the New Player of Neuroinflammatory Process in Multiple SclerosisSemantic proximity Read ↗

The role of microRNA-16 in the pathogenesis of autoimmune diseases: A comprehensive reviewSemantic proximity Read ↗

Integrative Analysis of lncRNAs in Th17 Cell Lineage to Discover New Potential Biomarkers and Therapeutic Targets in Autoimmune DiseasesSemantic proximity Read ↗

Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAsSemantic proximity Read ↗

K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunitySemantic proximity Read ↗

Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.