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Th17 Cell, the New Player of Neuroinflammatory Process in Multiple Sclerosis

21 Feb 2011

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune disease characterized by recurrent episodes of demyelination and axonal lesion mediated by CD4(+) T cells with a proinflammatory Th1 and Th17 phenotype, macrophages, and soluble inflammatory mediators. Identification of Th17 cells led to breaking the dichotomy of Th1/Th2 axis in immunopathogenesis of autoimmune diseases such as MS, and its experimental model, experimental...

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PMID: 21338381
DOI: 10.1111/j.1365-3083.2011.02536.x

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