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K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity

19 Feb 2025

Abstract excerpt

BACKGROUND: The HECT E3 ubiquitin ligase Nedd4 has been shown to positively regulate T cell responses, but its role in T helper (Th) cell differentiation and autoimmunity is unknown. Th17 cells are believed to play a pivotal role in the development and pathogenesis of autoimmune diseases. Nevertheless, the regulation of RORγt activation during Th17 cell differentiation by TCR signaling is yet to be elucidated....

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PMID: 39972304
DOI: 10.1186/s12929-025-01120-2

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