MiR-9-5p and miR-106a-5p dysregulated in CD4+ T-cells of multiple sclerosis patients and targeted essential factors of T helper17/regulatory T-cells differentiation.

Abstract excerpt

OBJECTIVES: T cells in two groups of relapsing and remitting in our relapsing-remitting MS (RR-MS) patients. MATERIALS AND METHODS: T-cells by flow cytometry. We also investigated the role of these miRNAs in Th17/Treg differentiation pathway through bioinformatics tools. RESULTS: were up-regulated in relapsing and remitting phases of MS, respectively. CONCLUSION: Expression pattern of miR-9-5p and miR-106a-5p and...

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