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Article

VCPIP1 facilitates pancreatic adenocarcinoma progression via Hippo/YAP signaling

28 May 2025

Abstract excerpt

Dysregulation of Hippo signaling is observed in pancreatic adenocarcinoma (PAAD). Moreover, overactivation of YAP is crucial for tumor progression. Although the inhibitory phospho-cascade is functional, the reason for YAP hyperactivation in PAAD remains unclear. Recent studies have revealed that the ubiquitin modification of YAP also plays an important role in the Hippo/YAP axis and cancer progression. To gain a...

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PMID: 40436845
DOI: 10.1038/s41419-025-07746-2

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