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Article

Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma.

Oncogene - 2 Mar 2017

Murakami S, Shahbazian D, Surana R, Zhang W, Chen H, Graham G T, White S M, Weiner L M, Yi C

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a high degree of inflammation and profound immune suppression. Here we identify Yes-associated protein (Yap) as a critical regulator of the immunosuppressive microenvironment in both mouse and human PDAC. Within Kras:p53 mutant pancreatic ductal cells, Yap drives the expression and secretion of multiple cytokines/chemokines, which in turn promote the...

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Identifiers

PMID: 27546622
DOI: 10.1038/onc.2016.288
PMCID: PMC5322249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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