Article
Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas.
Breast cancer research : BCR - 14 Jan 2019
Hoffman Joshua, Fejerman Laura, Hu Donglei, Huntsman Scott, Li Min, John Esther M, Torres-Mejia Gabriela, Kushi Larry, Ding Yuan Chun, Weitzel Jeffrey, Neuhausen Susan L, Lott Paul, Echeverry Magdalena, Carvajal-Carmona Luis, Burchard Esteban, Eng Celeste, Long Jirong, Zheng Wei, Olopade Olufunmilayo, Huo Dezheng, Haiman Christopher, Ziv Elad
Abstract excerpt
BACKGROUND: Breast cancer is a partially heritable trait and genome-wide association studies (GWAS) have identified over 180 common genetic variants associated with breast cancer. We have previously performed breast cancer GWAS in Latinas and identified a strongly protective single nucleotide polymorphism (SNP) at 6q25, with the protective minor allele originating from indigenous American ancestry. Here we report...
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