Article
Ketogenic diet slows down mitochondrial myopathy progression in mice.
Human molecular genetics - 15 May 2010
Ahola-Erkkilä Sofia, Carroll Christopher J, Peltola-Mjösund Katja, Tulkki Valtteri, Mattila Ismo, Seppänen-Laakso Tuulikki, Oresic Matej, Tyynismaa Henna, Suomalainen Anu
Abstract excerpt
Mitochondrial dysfunction is a major cause of neurodegenerative and neuromuscular diseases of adult age and of multisystem disorders of childhood. However, no effective treatment exists for these progressive disorders. Cell culture studies suggested that ketogenic diet (KD), with low glucose and high fat content, could select against cells or mitochondria with mutant mitochondrial DNA (mtDNA), but proper patient...
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