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An elastic-net logistic regression approach to generate classifiers and gene signatures for types of immune cells and T helper cell subsets

22 Aug 2019

Abstract excerpt

BACKGROUND: Host immune response is coordinated by a variety of different specialized cell types that vary in time and location. While host immune response can be studied using conventional low-dimensional approaches, advances in transcriptomics analysis may provide a less biased view. Yet, leveraging transcriptomics data to identify immune cell subtypes presents challenges for extracting informative gene...

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PMID: 31438843
DOI: 10.1186/s12859-019-2994-z

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