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Article

Dual Role of p53 in Innate Antiviral Immunity

22 Jan 2010

Abstract excerpt

Tumor suppressor p53 is widely known as 'the guardian of the genome' due to its ability to prevent the emergence of transformed cells by the induction of cell cycle arrest and apoptosis. However, recent studies indicate that p53 is also a direct transcriptional target of type I interferons (IFNs) and thus, it is activated by these cytokines upon viral infection. p53 has been shown to contribute to virus-induced...

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PMID: 21994612
DOI: 10.3390/v2010298

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