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Article

p53 is an Important Regulator of CCL2 Gene Expression

1 Aug 2012

Abstract excerpt

The p53 protein is a sequence-specific DNA-binding factor that regulates inflammatory genes such as CCL2/MCP-1 that may play a role in various diseases. A recent study has indicated that the knockdown of human p53 leads to a strong negative regulation of CCL2 induction. We are therefore interested in how p53 regulates CCL2 gene expression. In the following study, our findings indicate that UV-induced p53...

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PMID: 22804246
DOI: 10.2174/156652412802480844

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