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Article

Early patterning and specification of cardiac progenitors in gastrulating mesoderm

8 Oct 2014

Abstract excerpt

Mammalian heart development requires precise allocation of cardiac progenitors. The existence of a multipotent progenitor for all anatomic and cellular components of the heart has been predicted but its identity and contribution to the two cardiac progenitor 'fields' has remained undefined. Here we show, using clonal genetic fate mapping, that Mesp1+ cells in gastrulating mesoderm are rapidly specified into...

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PMID: 25296024
DOI: 10.7554/elife.03848

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