RF_Purify: a novel tool for comprehensive analysis of tumor-purity in methylation array data based on random forest regression

Abstract excerpt

BACKGROUND: With the advent of array-based techniques to measure methylation levels in primary tumor samples, systematic investigations of methylomes have widely been performed on a large number of tumor entities. Most of these approaches are not based on measuring individual cell methylation but rather the bulk tumor sample DNA, which contains a mixture of tumor cells, infiltrating immune cells and other stromal...

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