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Article

Prognostic Relevance of Tumor Purity and Interaction with MGMT Methylation in Glioblastoma.

Molecular cancer research : MCR - 1 May 2017

Schulze Heuling Eva, Knab Felix, Radke Josefine, Eskilsson Eskil, Martinez-Ledesma Emmanuel, Koch Arend, Czabanka Marcus, Dieterich Christoph, Verhaak Roel G, Harms Christoph, Euskirchen Philipp

Abstract excerpt

Promoter methylation status of O-6-methylguanine-DNA methyltransferase (MGMT), a DNA repair enzyme, is a critical biomarker in glioblastoma (GBM), as treatment decisions and clinical trial inclusion rely on its accurate assessment. However, interpretation of results is complicated by poor interassay reproducibility as well as a weak correlation between methylation status and expression levels of MGMT. This study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28148826
DOI: 10.1158/1541-7786.MCR-16-0322

Genes

MGMT
IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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