Article
Bipyridine (2,2'-dipyridyl) potentiates Escherichia coli lethality induced by nitrogen mustard mechlorethamine.
Mutation research - 1 Jul 2014
De Alencar T A M, Wilmart-Gonçalves T C, Vidal L S, Fortunato R S, Leitão A C, Lage C
Abstract excerpt
Alkylating agents are used in anti-tumor chemotherapy because they bind covalently to DNA and generate adducts that may lead to cell death. Bifunctional (HN2) and monofunctional (HN1) nitrogen are two such agents, and HN2 was the first drug successfully employed in anti-leukemia chemotherapy. Currently, HN2 is used either alone or combined with other drugs to treat Hodgkin's disease. It is well known that several...
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