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Mowat-Wilson syndrome factor ZEB2 controls early formation of human neural crest through BMP signaling modulation

26 Oct 2023

Abstract excerpt

Mowat-Wilson syndrome is caused by mutations in ZEB2, with patients exhibiting characteristics indicative of neural crest (NC) defects. We examined the contribution of ZEB2 to human NC formation using a model based on human embryonic stem cells. We found ZEB2 to be one of the earliest factors expressed in prospective human NC, and knockdown revealed a role for ZEB2 in establishing the NC state while repressing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37890485
DOI: 10.1016/j.stemcr.2023.10.002

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