Article

Analysis of long and short enhancers in melanoma cell states

2021-07-27

Abstract excerpt

Understanding how enhancers drive cell type specificity and efficiently identifying them is essential for the development of innovative therapeutic strategies. In melanoma, the melanocytic (MEL) and the mesenchymal-like (MES) states present themselves with different responses to therapy, making the identification of specific enhancers highly relevant. Using massively parallel reporter assay (MPRA) in a panel of pa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4f086ae3-c231-559c-8577-2909f73b3970
DOI: 10.1101/2021.07.27.453936

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of long and short enhancers in melanoma cell statesDOI 10.1101/2021.07.27.453936Read

Cross-species analysis of melanoma enhancer logic using deep learningSemantic proximity Read

Super-Enhancers Orchestrate Transcriptional Dysregulation and Metabolic Reprogramming in Uveal MelanomaSemantic proximity Read

MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells.Semantic proximity Read

Landscape of enhancer disruption and functional screen in melanoma cells.Semantic proximity Read

Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma.Semantic proximity Read

Interpretation of allele-specific chromatin accessibility using cell state-aware deep learning.Semantic proximity Read

Comprehensive Evaluation of Diverse Massively Parallel Reporter Assays to Functionally Characterize Human Enhancers Genome-wideSemantic proximity Read

Massively parallel reporter assays combined with cell-type specific eQTL informed multiple melanoma loci and identified a pleiotropic function of HIV-1 restriction gene, <i>MX2</i> , in melanoma promotionSemantic proximity Read

Epigenomic profiling of neuroblastoma cell linesSemantic proximity Read

Melanoma-specific mutation hotspots in distal, non-coding, promoter-interacting regions implicate novel candidate driver genes.Semantic proximity Read

Mapping chromatin interactions at melanoma susceptibility loci and cell-type specific dataset integration uncovers distant gene targets of<i>cis</i>-regulationSemantic proximity Read

Mapping chromatin interactions at melanoma susceptibility loci uncovers distant cis-regulatory gene targets.Semantic proximity Read