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Article

Cryptic exon inclusion is a molecular signature of LATE-NC in aging brains

3 Feb 2024

Abstract excerpt

The aggregation, mislocalization, and phosphorylation of TDP-43 are pathologic hallmarks of several neurodegenerative diseases and provide a defining criterion for the neuropathologic diagnosis of Limbic-predominant Age-related TDP-43 Encephalopathy (LATE). LATE neuropathologic changes (LATE-NC) are often comorbid with other neurodegenerative pathologies including Alzheimer's disease neuropathologic changes...

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PMID: 38308693
DOI: 10.1007/s00401-023-02671-0

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