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Article

Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly.

Neuro-degenerative diseases - 1 Jan 2010

Dickson Dennis W, Baker Matthew, Rademakers Rosa

Abstract excerpt

BACKGROUND: Hippocampal sclerosis (HpScl) is common in elderly subjects with dementia, either alone or accompanied by other pathologic processes. It is also found in >70% of frontotemporal lobar degeneration with TDP-43 immunoreactive inclusions (FTLD-TDP). TDP-43 inclusions are detected in >20%...

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Source

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Identifiers

PMID: 20197700
DOI: 10.1159/000289231
PMCID: PMC2859236

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-20197700-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly.PMID 20197700Read ↗

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CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.Semantic proximity Read ↗

GRN variability contributes to sporadic frontotemporal lobar degeneration.Semantic proximity Read ↗

Variation at GRN 3'-UTR rs5848 is not associated with a risk of frontotemporal lobar degeneration in Dutch population.Semantic proximity Read ↗

Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease.Semantic proximity Read ↗

A mutation in the 5'-UTR of GRN gene associated with frontotemporal lobar degeneration: phenotypic variability and possible pathogenetic mechanisms.Semantic proximity Read ↗

GRN Missense Variants and Familial Alzheimer's Disease: Two Case Reports.Semantic proximity Read ↗

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