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Article

Transcriptomic signatures of brain regional vulnerability to Parkinson's disease.

Communications biology - 5 Mar 2020

Keo Arlin, Mahfouz Ahmed, Ingrassia Angela M T, Meneboo Jean-Pascal, Villenet Celine, Mutez Eugénie, Comptdaer Thomas, Lelieveldt Boudewijn P F, Figeac Martin, Chartier-Harlin Marie-Christine, van de Berg Wilma D J, van Hilten Jacobus J, Reinders Marcel J T

Abstract excerpt

The molecular mechanisms underlying caudal-to-rostral progression of Lewy body pathology in Parkinson's disease remain poorly understood. Here, we identified transcriptomic signatures across brain regions involved in Braak Lewy body stages in non-neurological adults from the Allen Human Brain Atlas. Among the genes that are indicative of regional vulnerability, we found known genetic risk factors for Parkinson's...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32139796
DOI: 10.1038/s42003-020-0804-9
PMCID: PMC7058608

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