Article
Mortality differences by APOE genotype estimated from demographic synthesis.
Genetic epidemiology - 1 Feb 2002
Ewbank Douglas C
Abstract excerpt
The 4 allele of apolipoprotein E (APOE) is associated with increased risk of two major causes of death in low-mortality populations: ischemic heart disease and Alzheimer's disease. It is less common among centenarians than at younger ages. Therefore, it is likely that it is associated with excess risk of death. This article extends demographic models that estimate relative mortality risks from changes in gene...
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