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Bypassing pan-enterovirus host factor PLA2G16

18 Jul 2019

Abstract excerpt

Enteroviruses are a major cause of human disease. Adipose-specific phospholipase A2 (PLA2G16) was recently identified as a pan-enterovirus host factor and potential drug target. In this study, we identify a possible mechanism of PLA2G16 evasion by employing a dual glycan receptor-binding enterovirus D68 (EV-D68) strain. We previously showed that this strain does not strictly require the canonical EV-D68 receptor...

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PMID: 31320648
DOI: 10.1038/s41467-019-11256-z

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