Article
PLA2G16 represents a switch between entry and clearance of Picornaviridae.
Nature - 19 Jan 2017
Staring Jacqueline, von Castelmur Eleonore, Blomen Vincent A, van den Hengel Lisa G, Brockmann Markus, Baggen Jim, Thibaut Hendrik Jan, Nieuwenhuis Joppe, Janssen Hans, van Kuppeveld Frank J M, Perrakis Anastassis, Carette Jan E, Brummelkamp Thijn R
Abstract excerpt
Picornaviruses are a leading cause of human and veterinary infections that result in various diseases, including polio and the common cold. As archetypical non-enveloped viruses, their biology has been extensively studied. Although a range of different cell-surface receptors are bound by different picornaviruses, it is unclear whether common host factors are needed for them to reach the cytoplasm. Using...
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