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Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein

14 Feb 2022

Abstract excerpt

Abstract SARS-CoV-2 infection is a major global public health concern with incompletely understood pathogenesis. The SARS-CoV-2 spike (S) glycoprotein comprises a highly conserved free fatty acid binding pocket (FABP) with unknown function and evolutionary selection advantage 1,2 . Deciphering FABP impact on COVID-19 progression is challenged by the heterogenous nature and large molecular variability of live...

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PMID: 35165285
DOI: 10.1038/s41467-022-28446-x

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