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Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection

29 Oct 2022

Abstract excerpt

Communicable respiratory viral infections pose both epidemic and pandemic threats and broad-spectrum antiviral strategies could improve preparedness for these events. To discover host antiviral restriction factors that may act as suitable targets for the development of host-directed antiviral therapies, we here conduct a whole-genome CRISPR activation screen with influenza B virus (IBV). A top hit from our...

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PMID: 36309510
DOI: 10.1038/s41467-022-34111-0

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