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The Coronavirus Envelope Is Modulated by Host Inflammation and Enriched in Bioactive Lipids Required for Replication

2025-11-03

Abstract excerpt

How inflammation or disease regulates coronavirus lipid membranes is currently unknown, while patient-derived viral envelopes have never been structurally characterized. Here, we show that four cultured SARS-CoV-2 strains (England2, Alpha, Beta, and Delta) possess conserved, phospholipid- and cholesterol-rich envelopes, with pro-thrombotic and infection-promoting aminophospholipids (aPL) displayed predominantly on...

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Literature Corpus work
8f1af0fd-db89-5486-a125-cc8ea619b183
DOI
10.1101/2025.11.03.686211
Open publication

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