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Article

The role of mutations associated with familial neurodegenerative disorders on blood–brain barrier function in an iPSC model

14 Jul 2019

Abstract excerpt

BACKGROUND: Blood-brain barrier dysfunction is associated with many late-stage neurodegenerative diseases. An emerging question is whether the mutations associated with neurodegenerative diseases can independently lead to blood-brain barrier (BBB) dysfunction. Studies from patient-derived induced pluripotent stem cells suggest that mutations associated with neurodegenerative disease are non-cell autonomous,...

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PMID: 31303172
DOI: 10.1186/s12987-019-0139-4

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