Article
Mutational signature assignment heterogeneity is widespread and can be addressed by ensemble approaches.
Briefings in bioinformatics - 22 Sept 2023
Wu Andy J, Perera Akila, Kularatnarajah Linganesan, Korsakova Anna, Pitt Jason J
Abstract excerpt
Single-base substitution (SBS) mutational signatures have become standard practice in cancer genomics. In lieu of de novo signature extraction, reference signature assignment allows users to estimate the activities of pre-established SBS signatures within individual malignancies. Several tools have been developed for this purpose, each with differing methodologies. However, due to a lack of standardization, there...
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