Article
Towards personalized therapy for patients with malignant melanoma: molecular insights into the biology of BRAF mutations.
Future oncology (London, England) - 1 Feb 2013
Bradish Joshua R, Montironi Rodolfo, Lopez-Beltran Antonio, Post Kristin M, MacLennan Gregory T, Cheng Liang
Abstract excerpt
BRAF mutations have been identified as the most common oncogene mutation in melanomas, especially important in those originating on nonchronically sun-damaged skin. There is a large and continually growing body of evidence regarding the importance of this mutation in targeted therapy for melanoma. In this review, we outline these findings including: molecular pathways used by BRAF, the importance in nonmalignant...
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