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Article

Toxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson's Disease Brains Are Differentially Generated in Mammalian Cell Models.

Biomolecules - 22 Jul 2015

Xin Wei, Emadi Sharareh, Williams Stephanie, Liu Qiang, Schulz Philip, He Ping, Alam Now Bahar, Wu Jie, Sierks Michael R

Abstract excerpt

Misfolding and aggregation of α-synuclein into toxic soluble oligomeric α-synuclein aggregates has been strongly correlated with the pathogenesis of Parkinson's disease (PD). Here, we show that two different morphologically distinct oligomeric α-synuclein aggregates are present in human post-mortem PD brain tissue and are responsible for the bulk of α-synuclein induced toxicity in brain homogenates from PD...

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Identifiers

PMID: 26287258
DOI: 10.3390/biom5031634
PMCID: PMC4598768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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