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Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations

1 Jul 2019

Abstract excerpt

The HIV-1 envelope (Env) is the target for neutralizing antibodies and exists on the surface of virions in open or closed conformations. Difficult-to-neutralize viruses (tier 2) express Env in a closed conformation antigenic for broadly neutralizing antibodies (bnAbs) but not for third variable region (V3) antibodies. Here we show that select V3 macaque antibodies elicited by Env vaccination can neutralize 26% of...

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PMID: 31263112
DOI: 10.1038/s41467-019-10899-2

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