Article
Functional Stability of HIV-1 Envelope Trimer Affects Accessibility to Broadly Neutralizing Antibodies at Its Apex.
Journal of virology - 15 Dec 2017
Gift Syna Kuriakose, Leaman Daniel P, Zhang Lei, Kim Arthur S, Zwick Michael B
Abstract excerpt
The trimeric envelope glycoprotein spike (Env) of HIV-1 is the target of vaccine development to elicit broadly neutralizing antibodies (bnAbs). Env trimer instability and heterogeneity in principle make subunit interfaces inconsistent targets for the immune response. Here, we investigate how functional stability of Env relates to neutralization sensitivity to V2 bnAbs and V3 crown antibodies that engage subunit...
Topics
- Antibodies, Neutralizing
- Epitopes
- Glycosylation
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Mutation
- Peptide Fragments
- Protein Binding
- Protein Stability
- env Gene Products, Human Immunodeficiency Virus