Article
HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees.
Journal of virology - 15 Apr 2018
Yates Nicole L, deCamp Allan C, Korber Bette T, Liao Hua-Xin, Irene Carmela, Pinter Abraham, Peacock James, Harris Linda J, Sawant Sheetal, Hraber Peter, Shen Xiaoying, Rerks-Ngarm Supachai, Pitisuttithum Punnee, Nitayapan Sorachai, Berman Phillip W, Robb Merlin L, Pantaleo Giuseppe, Zolla-Pazner Susan, Haynes Barton F, Alam S Munir, Montefiori David C, Tomaras Georgia D
Abstract excerpt
Induction of broadly cross-reactive antiviral humoral responses with the capacity to target globally diverse circulating strains is a key goal for HIV-1 immunogen design. A major gap in the field is the identification of diverse HIV-1 envelope antigens to evaluate vaccine regimens for binding antibody breadth. In this study, we define unique antigen panels to map HIV-1 vaccine-elicited antibody breadth and...
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