Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses.

doi:10.1016/j.chom.2015.08.006

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Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses.

Cell host & microbe - 9 Sept 2015

Moody M Anthony, Gao Feng, Gurley Thaddeus C, Amos Joshua D, Kumar Amit, Hora Bhavna, Marshall Dawn J, Whitesides John F, Xia Shi-Mao, Parks Robert, Lloyd Krissey E, Hwang Kwan-Ki, Lu Xiaozhi, Bonsignori Mattia, Finzi Andrés, Vandergrift Nathan A, Alam S Munir, Ferrari Guido, Shen Xiaoying, Tomaras Georgia D, Kamanga Gift, Cohen Myron S, Sam Noel E, Kapiga Saidi, Gray Elin S, Tumba Nancy L, Morris Lynn, Zolla-Pazner Susan, Gorny Miroslaw K, Mascola John R, Hahn Beatrice H, Shaw George M, Sodroski Joseph G, Liao Hua-Xin, Montefiori David C, Hraber Peter T, Korber Bette T, Haynes Barton F

Abstract excerpt

The third variable (V3) loop and the CD4 binding site (CD4bs) of the HIV-1 envelope are frequently targeted by neutralizing antibodies (nAbs) in infected individuals. In chronic infection, HIV-1 escape mutants repopulate the plasma, and V3 and CD4bs nAbs emerge that can neutralize heterologous tier 1 easy-to-neutralize but not tier 2 difficult-to-neutralize HIV-1 isolates. However, neutralization sensitivity of...

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Identifiers

PMID: 26355218
DOI: 10.1016/j.chom.2015.08.006
PMCID: PMC4567706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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