Article

Alternative substitutions of N332 in HIV-1 <sub>AD8</sub> gp120 differentially affect envelope glycoprotein function and viral sensitivity to broadly neutralizing antibodies targeting the V3-glycan

2023-11-21

Abstract excerpt

<h4>ABSTRACT</h4> The envelope glycoprotein (Env) trimer on the surface of human immunodeficiency virus type I (HIV-1) mediates viral entry into host CD4+ T cells and is the sole target of neutralizing antibodies. Broadly neutralizing antibodies (bnAbs) that target gp120 V3-glycan of HIV-1 Env trimer are potent and block the entry of diverse HIV-1 strains. Most V3-glycan bnAbs interact, to a different extent, wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 39272ae1-815f-56ab-96f9-3380c9275900
DOI: 10.1101/2023.11.20.567910

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alternative substitutions of N332 in HIV-1 <sub>AD8</sub> gp120 differentially affect envelope glycoprotein function and viral sensitivity to broadly neutralizing antibodies targeting the V3-glycanDOI 10.1101/2023.11.20.567910Read

Alternative substitutions of N332 in HIV-1 AD8 gp120 differentially affect envelope glycoprotein function and viral sensitivity to broadly neutralizing antibodies targeting the V3-glycanSemantic proximity Read

Identification of a broad and potent V3 glycan site bNAb targeting an N332 <sub>gp120</sub> glycan-independent epitopeSemantic proximity Read

Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelopeSemantic proximity Read

Cooperation between Strain-Specific and Broadly Neutralizing Responses Limited Viral Escape and Prolonged the Exposure of the Broadly Neutralizing Epitope.Semantic proximity Read

HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bondsSemantic proximity Read

Structural Rearrangements Maintain the Glycan Shield of an HIV-1 Envelope Trimer After the Loss of a GlycanSemantic proximity Read

Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope SpikeSemantic proximity Read

Functional and Highly Crosslinkable HIV-1 Envelope Glycoproteins Enriched in a Pretriggered ConformationSemantic proximity Read

Dual role of glycosylation in resistance to CD4-binding site broadly neutralizing antibodies.Semantic proximity Read

Structure/Function Studies Involving the V3 Region of the HIV-1 Envelope Delineate Multiple Factors That Affect Neutralization SensitivitySemantic proximity Read

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 coreSemantic proximity Read

Genetic signatures in the highly virulent subtype B HIV-1 conferring immune escape to V1/V2 and V3 broadly neutralizing antibodiesSemantic proximity Read