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Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol

27 May 2021

Abstract excerpt

Genetics are a known contributor to differences in alcohol sensitivity in humans with fetal alcohol spectrum disorders (FASDs) and in animal models. Our study profiled gene expression in gastrulation-stage embryos from two commonly used, genetically similar mouse substrains, C57BL/6J (6J) and C57BL/6NHsd (6N), that differ in alcohol sensitivity. First, we established normal gene expression patterns at three...

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PMID: 34137816
DOI: 10.1242/dmm.049012

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