Article

Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice

2017-02-27

Abstract excerpt

<h4>Background: </h4> Identifying genes that are essential for mouse embryonic development and survival through term is a powerful and unbiased way to discover possible genetic determinants of human developmental disorders. Characterising the changes in mouse embryos that result from ablation of lethal genes is a necessary first step towards uncovering their role in normal embryonic development and establishing an...

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Literature Corpus work: 7b69a34d-03d3-522e-8cca-218d844c29ca
DOI: 10.12688/wellcomeopenres.9899.2

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