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Article

Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation

25 Jun 2019

Abstract excerpt

BACKGROUND: The human immunodeficiency virus (HIV) cell reservoir is currently a main obstacle towards complete eradication of the virus. This infected pool is refractory to anti-viral therapy and harbors integrated proviruses that are transcriptionally repressed but replication competent. As transcription silencing is key for establishing the HIV reservoir, significant efforts have been made to understand the...

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PMID: 31238957
DOI: 10.1186/s12977-019-0478-x

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