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Article

Genetic alterations in the NO-cGMP pathway and cardiovascular risk.

Nitric oxide : biology and chemistry - 1 Jun 2018

Wobst Jana, Schunkert Heribert, Kessler Thorsten

Abstract excerpt

In the past ten years, several chromosomal loci have been identified by genome-wide association studies to influence the risk of coronary artery disease (CAD) and its risk factors. The GUCY1A3 gene encoding the α1 subunit of the soluble guanylyl cyclase (sGC) resides at one of these loci and has been strongly associated with blood pressure and CAD risk. More recently, further genes in the pathway encoding the...

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Identifiers

PMID: 29601927
DOI: 10.1016/j.niox.2018.03.019

Genes

CAD
NOS3

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