Article

Dissecting transcriptional heterogeneity in multiple primary lung cancer by single cell RNA sequencing

2022-06-03

Abstract excerpt

The progression of multiple primary lung cancer (MPLC) involves complex changes in cell composition and metabolic function. Here, we performed scRNA sequencing of 167,397 cells from six patients with MPLC, combined with bulk whole-exome sequencing. We revealed that both naïve and memory T cells participate in the differentiation of CD8+ T cells. The terminal states of CD8+ T cells are exhausted T cells, which resp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 943078b7-80b8-526c-aad4-b60e36f6b146
DOI: 10.21203/rs.3.rs-1716190/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dissecting transcriptional heterogeneity in multiple primary lung cancer by single cell RNA sequencingDOI 10.21203/rs.3.rs-1716190/v1Read

Single‐cell RNA sequencing analysis reveals transcriptional heterogeneity of multiple primary lung cancerSemantic proximity Read

Decoding the multicellular ecosystem of lung adenocarcinoma manifested as pulmonary subsolid nodules by single-cell RNA sequencingSemantic proximity Read

Landscape and dynamics of single tumor and immune cells in early and advanced‐stage lung adenocarcinomaSemantic proximity Read

Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations.Semantic proximity Read

Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma.Semantic proximity Read

Single-cell RNA sequencing reveals potential therapeutic targets in the tumor microenvironment of lung squamous cell carcinomaSemantic proximity Read

Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages.Semantic proximity Read

Single-cell transcriptomic profiling reveals the tumor heterogeneity of small-cell lung cancerSemantic proximity Read

Single-cell analysis of diverse immune phenotypes in malignant pleural effusionSemantic proximity Read

Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stagesSemantic proximity Read

Characterizing Tumor Microenvironment and Risk Genes in Lung Adenocarcinoma through scRNA-seq and Bulk RNA-seq DataSemantic proximity Read

Genomic characteristics and immune landscape of super multiple primary lung cancer.Semantic proximity Read