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Article

Pak2 kinase promotes cellular senescence and organismal aging

17 Jun 2019

Abstract excerpt

Cellular senescence defines an irreversible cell growth arrest state linked to loss of tissue function and aging in mammals. This transition from proliferation to senescence is typically characterized by increased expression of the cell-cycle inhibitor p16 INK4a and formation of senescence-associated heterochromatin foci (SAHF). SAHF formation depends on HIRA-mediated nucleosome assembly of histone H3.3, which is...

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PMID: 31209047
DOI: 10.1073/pnas.1903847116

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