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Article

H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence

21 May 2012

Abstract excerpt

Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. Here we combine quantitative mass spectrometry, ChIP deep-sequencing, and functional studies to determine the role of histone modifications on chromatin structure and gene-expression alterations associated with senescence in primary human...

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Share to Epigenetics and DNA Methylation
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Share to Telomeres, Telomerase, and Senescence

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PMID: 22615382
DOI: 10.1073/pnas.1119836109

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