Pak4 Induces Premature Senescence via a Pathway Requiring p16 INK4 /p19 ARF and Mitogen-Activated Protein Kinase Signaling

Abstract excerpt

Exposure of primary cells to mitogenic stimuli or oncogenes often causes them to undergo premature senescence. This is most likely a protective function that prevents uncontrolled proliferation. Pak4 is a target for the Rho GTPase Cdc42. Pak4 is overexpressed in human tumor cell lines, and it is the only member of the Pak family that is highly transforming in immortalized fibroblasts. Here we show that in primary...

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