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Article

Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex.

Biochemistry - 3 Mar 2020

Zhao Bin, Payne William G, Sai Jiqing, Lu Zhenwei, Olejniczak Edward T, Fesik Stephen W

Abstract excerpt

KLHL-12 is a substrate specific adapter protein for a Cul3-Ring ligase complex. It is a member of the Kelch β-propeller domain subclass of Cullin-Ring substrate recognition domains. This E3 ubiquitin ligase complex has many activities, including acting as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of Dvl3/Dsh3. KLHL-12 is also known to mediate the...

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PMID: 32032490
DOI: 10.1021/acs.biochem.9b01073

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