Article
Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 2016
Gorelik Maryna, Orlicky Stephen, Sartori Maria A, Tang Xiaojing, Marcon Edyta, Kurinov Igor, Greenblatt Jack F, Tyers Mike, Moffat Jason, Sicheri Frank, Sidhu Sachdev S
Abstract excerpt
Skp1-Cul1-F-box (SCF) E3 ligases play key roles in multiple cellular processes through ubiquitination and subsequent degradation of substrate proteins. Although Skp1 and Cul1 are invariant components of all SCF complexes, the 69 different human F-box proteins are variable substrate binding modules that determine specificity. SCF E3 ligases are activated in many cancers and inhibitors could have therapeutic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.